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Various stimuli can activate AP-1, such as extracellular growth factors, oxidative stress, pro-inflammatory cytokines, interferons, and the intracellular PI3K/Akt and MAPK signaling pathways [19]

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Specifically, semaglutide reduced total fat mass and visceral fat mass (generally considered to be unhealthy fat) and increased the proportion of lean body mass in adults with overweight or obesity

doi: 10.1371/journal.pone.0138494 51 Gonzlez-AguilarG